Searchable abstracts of presentations at key conferences in endocrinology

ea0099ep266 | Adrenal and Cardiovascular Endocrinology | ECE2024

In vitro differentiation of mouse pluripotent stem cells into glucocorticoid-producing adrenocortical cells

Oikonomakos Ioannis , Neirijnck Yasmine , Tedesco Melina , Jian Motamedi Fariba , Nef Serge , Bornstein Stefan , Steenblock Charlotte , Schedl Andreas

The adrenal cortex, a pivotal endocrine regulator governing body homeostasis, metabolism, and stress response through steroid hormone synthesis, presents formidable challenges for effective replacement in disorders like adrenal insufficiency and congenital adrenal hyperplasia. The limitations of current hormone replacement strategies stem from the intricate dynamics of hormonal release. This study harnesses insights derived from the analysis of a recently published single-cell...